Neuro-Oncology

Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy.

Neuro-Oncology

Lin K, Zou C, Hubbard A, Sengelmann S, Goudy L, Wang IC, Sharma R, Pak J, Foster K, Ozawa T, de Groot JF, Phillips J, Vasudevan HN, Raleigh DR, Marson A, Murthy N, Gilbert LA, Berger MS, Liu SJ

EXTH-68. EPIGENETIC EDITING BY MRNA-BASED CRISPROFF ENABLES FLEXIBLE AND DURABLE TARGETING OF GLIOBLASTOMA DRIVERS MGMT AND TERT.

Neuro-Oncology

Katie Lin, Christopher Zou, Laine Goudy, Rohit Sharma, Nicholas O Stevers, Joanna Pak, Kyla Foster, Emily Payne, Anny Shai, Tomoko Ozawa, John F de Groot, Harish Vasudevan, Joanna J Phillips, David R Raleigh, Joseph F Costello, Niren Murthy, Luke A Gilbert, Mitchel Berger, S John Liu

OS07.1.A INTEGRATIVE SINGLE NUCLEI, SPATIAL, AND FUNCTIONAL GENOMIC ANALYSES REVEAL DNA-PK DRIVES GLIOBLASTOMA RADIORESISTANCE THROUGH TUMOR CELLS AND THE MYELOID MICROENVIRONMENT.

Neuro-Oncology

J Liu, N Majd, C Zou, K Mirchia, J Pak, K Foster, K Lin, T Casey-Clyde, K Seo, S Pan, E Payne, H Vasudevan, T Ozawa, M Berger, J de Groot, W Weiss, L Gilbert, D Raleigh

EXTH-78. CRISPROFF EPIGENOME EDITING AND FUNCTIONAL GENOMICS DEFINE MEDIATORS OF CHEMOTHERAPY RESISTANCE IN GLIOBLASTOMA.

Neuro-Oncology

Katie Lin, Laine Goudy, Joanna Pak, Kyla Foster, Emily Payne, Tomoko Ozawa, John de Groot, Harish Vasudevan, David Raleigh, Luke Gilbert, Mitchel Berger, John Liu

EPCO-12. IN VIVO PERTURB-SEQ DEFINES BIOLOGICAL DRIVERS AND THERAPEUTIC VULNERABILITIES UNDERLYING RADIOTHERAPY RESISTANCE IN GLIOBLASTOMA.

Neuro-Oncology

John Liu, Joanna Pak, Christopher Zou, Sixuan Pan, Emily Payne, Kyla Foster, Katie Lin, Tim Casey-Clyde, Kyounghee Seo, Thomas O'Loughlin, David Wu, Daniel Lim, Harish Vasudevan, Aaron Diaz, Tomoko Ozawa, Mitchel Berger, John de Groot, William Weiss, Luke Gilbert, David Raleigh

DRES-01. ZEB1-MEDIATED INVASIVE MESENCHYMAL TRANSITION AT THE SINGLE CELL LEVEL PROMOTES ANTI-ANGIOGENIC THERAPY RESISTANCE IN GLIOBLASTOMA.

Neuro-Oncology

Ankush Chandra, Arman Jahangiri, William Chen, Garima Yagnik, Joseph Garcia, Alan Nguyen, Jacob Weiss, Kayla Wolf, Jung-Ming Lin, Soeren Mueller, Jonathan Rick, Aaron Diaz, Luke Gilbert, Sanjay Kumar, Manish Aghi