The Gilbert laboratory's expertise is in synthetic biology, functional genomics and cancer biology. We are interested in new ways to model and overcome drug resistance in prostate cancer, hematopoietic malignancies and lung cancer. We use genome scale screens, genetic interaction mapping and genome engineering to model and map the genetic and epigenetic causes underlying why some patients are cured and others are not by cancer therapy. We are also building new CRISPR tools to edit the epigenome which will allow us to manipulate gene expression in new ways.